PFKFB3 and neoplasm: However, the accumulation of 18F-FDG mainly revels the activity of glucose transporters (GLUT) in tumor cells and tissues, the biomarker for tumor glycolysis may play more important role in tumor diagnosis, such as PFKFB3 (Ganapathy-Kanniappan and Geschwind, 2013; Meziou et al., 2020).