HMOX1 and endometrial carcinoma: Juglone can induce the accumulation of Fe2+, lipid peroxidation, GSH depletion, up-regulation of HMOX1, and heme degradation to Fe2+ in endometrial carcinoma cells, and also participates in inducing autophagy and inhibiting cell migration and ER stress, which may be a new marker for cancer treatment [30].