As FL and prM targeting Abs are the major species demonstrated to cause ADE in vitro and are thought to be responsible for ADE-driven negative outcomes after primary infection and vaccination,10–12,32 we propose that genetic ablation of the FL and prM epitopes in vaccine strains will minimize the production of these subclasses of Abs responsible for undesirable vaccine responses. Here, DDX41 is linked to acute disseminated encephalomyelitis.