Indeed, the endosome-lysosomal system appears to be a major pathway affected by aging and AD, with many changed proteins associated with lysosomes, notably involved in lysosomal quality control (LQC) altered in aging (e.g. CNN2, HspB1) and AD (e.g. DPP7, PLBD2, PLD3, TAGLN). The gene discussed is CNN2; the disease is Alzheimer disease.