CD8A and neoplasm: Besides, Bucsek et al. found Tregs and programmed death receptor-1 (PD-1) overexpression in mice exposed to cold stress and showed that mice housed at thermoneutral temperature of 30°C exhibited an anti-tumor immune microenvironment with higher number of CD8+ T cells and lower number of MDSCs and T-regs than mice that were kept at the sub-thermoneutral temperature of 22°C [23].