Among the top most mutated genes in this cohort [33], one subtype is enriched in PIK3CA hotspot mutation H1047R/L (p = 0.0034) and KAT6B mutation (p = 0.036), while the other subtype (simple adenomas/carcinomas-enriched and with more lymph node invasion) is enriched in TP53 mutation (p = 0.043) (Fig. 1). Here, PIK3CA is linked to adenoma.