There are multiple putative mechanisms that interlink the pathogenesis of NAFLD and CKD including decreased adiponectin, activated protein kinase (AMPK) activity, and increased fibroblast growth factor 21 activity, increased fetuin‐A, mammalian target of rapamycin activity, and sodium–glucose cotransporter 2 (SGLT2) activity.120, 127. This evidence concerns the gene SLC5A2 and chronic kidney disease.