SERPINE1 and diabetic kidney disease: PAI is increased in CKD, and the glycoprotein is found to contribute to the promotion of renal fibrosis.86PAI facilitates cell migration of inflammatory compounds such as monocytes and myofibroblasts within the renal interstitium, promoting fibrogenesis. It also induces fibrosis by inhibiting intravascular and tissue fibrinolytic processes.87Both PAI‐1 and messenger ribonucleic acid protein are raised in chronic glomerulonephritis, diabetic nephropathy and FSGS. PAI‐1 abundance also correlates with degree of proteinuria.88