AGAP1 and craniofacial microsomia: It is notable that while variants within theAGAP1 protein-coding sequence have not been implicated inhuman disease, a variant intronic to AGAP1 has been associatedwith hemifacial microsomia (rs3754648, p = 5 ×10−13), a disease which affects the patterning of the faceand often coincides with dental phenotypes (114).