Mutations in PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing), a gene encoding a protein that produces PtdIns(3,5)P2 and plays important roles in the endocytosis and autophagy [134], are associated with autosomal dominant cataracts [135] and fleck corneal dystrophy [136]. Here, PIKFYVE is linked to cataract.