Endothelial dystrophies are linked to or caused by mutation of SLC4A11 (solute carrier family 4 member 11), COL8A2 (collagen type VIII alpha 2 chain), LOXHD1 (lipoxygenase homology PLAT domains 1), AGBL1 (AGBL carboxypeptidase 1), COL17A1 (collagen type XVII alpha 1 chain) or TCF4 (transcription factor 4). This evidence concerns the gene COL17A1 and corneal endothelial dystrophy.