Mutations in FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1), a gene encoding a Rab7 effector that binds to LC3 and PtdIns(3)P and regulates the transport of autophagosomes along with microtubules, are associated with autosomal recessive congenital cataracts [111-113]. The gene discussed is FYCO1; the disease is early-onset non-syndromic cataract.