In Col8a2Q455K/Q455K and Col8a2L450W/L450W mouse models of Fuchs corneal endothelial dystrophy, increased expression of LC3-I protein and DRAM1 (DNA Damage Regulated Autophagy Modulator 1) mRNA - the latter required for p53 triggered autophagy and apoptosis [58]. The gene discussed is DRAM1; the disease is Fuchs endothelial corneal dystrophy.