In addition, absence of individual participant data did not permit us to perform subgroup analyses of the assessed arterial stiffness indices according to the prior history of cardiovascular comorbidities or cardiovascular disease, or baseline medication of specific interest, with established beneficial effect on arterial stiffness indices, such as renin-angiotensin-aldosterone blockers, or the baseline immunosuppressive treatment. The gene discussed is REN; the disease is cardiovascular disorder.