The risk of HF among female patients was associated with higher prevalence of type 2 diabetes (OR = 3.600, 95%CI, 2.032–6.379, P < 0.001), use of oral antidiabetics or insulin (OR = 3.179, 95%CI, 1.823–5.509, P < 0.001), morbidity of MI (OR =, 14.837 95%CI, 7.647–28.787, P < 0.001), and proportion of performed PCI (OR = 2.065, 95%CI, 1.156–3.688, P = 0.014). The gene discussed is INS; the disease is hydrops fetalis.