Hu et al. found that ACAG (>21.25 mmol/L) could predict the risk of in-hospital mortality in ICU patients with sepsis, and the predictive value of ACAG was superior to AG and albumin (13).The current evidence suggested that elevated ACAG (>20 mmol/L) at the initiation of continuous renal replacement therapy (CRRT) was associated with ICU all-cause mortality in AKI patients who underwent CRRT, and ACAG can serve as an early indicator of adverse outcomes for these patients (14). This evidence concerns the gene ALB and Sepsis.