ALB and acute kidney injury: Hu et al. found that ACAG (>21.25 mmol/L) could predict the risk of in-hospital mortality in ICU patients with sepsis, and the predictive value of ACAG was superior to AG and albumin (13).The current evidence suggested that elevated ACAG (>20 mmol/L) at the initiation of continuous renal replacement therapy (CRRT) was associated with ICU all-cause mortality in AKI patients who underwent CRRT, and ACAG can serve as an early indicator of adverse outcomes for these patients (14).