Previous studies have shown that exposure to high levels of androgens during the critical periods of development (prenatal or early postnatal life); results in an increase in the GnRH surge-generating system and increased LH levels (7, 8); consequently, androgen excess that is one of the main endocrine abnormalities in PCOS subjects (20, 21). The gene discussed is GNRH1; the disease is hyperandrogenism.