PPIG and familial hypercholesterolemia: It can be concluded from the linear correlation results that firstly the CYP enzyme selectivity of coumarin derivatives differ between humans and mice, and secondly, the CYP probe substrates used in this study mainly measured the effects of WD on CYP1, CYP2A, and CYP2B enzymes in hypercholesterolemia-inducing transgenic LDLr−/−ApoB100/100 male mice.