INS and Hyperglycemia: This model develops impaired insulin secretion by 2 weeks, impaired fasting hyperglycemia by 4 weeks, and displays retinal (Matsubara et al., 2006; Allen et al., 2019), cognitive (Moreira et al., 2007; Li et al., 2013; Allen et al., 2019), and motor nerve deficits (Suzuki et al., 1990).