With the onset of the accumulation of Aβ oligomers, the novel AD mouse model—PS1V97L-Tg expressing the human PS gene with the V97L mutation, show synaptic alteration, tau hyperphosphorylation, and glial activation, hence supporting an early role for this Aβ species and their role in neurotoxicity (Zhang et al., 2014). The gene discussed is MAPT; the disease is Alzheimer disease.