Karimian et al. (2022) explored the molecular mechanism of SARS-CoV-2-induced olfactory deficit, suggesting that OD may be a temporary or long-term complication caused by olfactory neuroepithelial disorders, with the Delta and Omicron strains relying on TMPRSS2 to enter cells and inducing inflammation, apoptosis, and neuronal damage. This evidence concerns the gene TMPRSS2 and osteochondritis dissecans.