In glaucoma, the changes in neurofilaments have been investigated in animal models but have remained controversial, as some bodies of research have observed a reduction in neurofilament heavy chain (NF-H) at the ONH in AOH (15, 16); conversely, the elevation of dephosphorylation or phosphorylated NF-H (pNF-H) has been demonstrated in some acute and chronic ocular hypertension (AOH, COH) models (17, 18). This evidence concerns the gene NEFH and glaucoma.