ACE and ischemic stroke: The ACE-DD genotype (OR = 3.71, 95% CI = 1.02–13.5; P < 0.05) and D allele (OR = 2.07, 95% CI = 1.06–4.03; P < 0.05) were significantly more common in patients than in controls, indicating that it is a risk factor for the development of ischemic stroke in hypertensive individuals.