APOE and Alzheimer disease: A study of cerebrospinal fluid from patients with AD pathology (beta-amyloid (Ab) and tau subtypes) but not yet symptomatic or in pre-dementia found elevated YKL-40, sTREM2, sAXL, sTyro3, MIF, complement factors C1q, C4 and H, ferritin, and ApoE inflammatory markers (61).