SOAT1 and amyotrophic lateral sclerosis: As seen by gene expression analysis of ALS astrocytes versus protective astrocytes, multiple genes appear opposite (65), signaling pathway analysis revealed that inflammatory pathways such as JAK-STAT, NF-kB and TNF are significantly increased in mouse ALS models, but C1q is able to inhibit the activation of these inflammatory pathways in phagocytes (101–103).