COX-2 overexpression in colon cancer cells leads to the production of prostaglandins and the induction of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulating endothelial cell migration and tube formation (43, 44). The gene discussed is VEGFA; the disease is malignant colon neoplasm.