We found that the expression of HIF1-α and HO-1 in the IRI group was higher than that in the Sham group, which indicated that when the rat kidney suffered ischemia-reperfusion injury, the oxidative stress response was activated and the secretion of antioxidant substances increased to combat the oxidative stress damage caused by renal ischemia-reperfusion. The gene discussed is HIF1A; the disease is ischemia reperfusion injury.