An increased amount of work has discovered that induction of adaptive immune responses by cancer cells undergoing ICD is dependent on the emission and detection of a particular panel of DAMPs, including cell surface-exposed calreticulin (CALR), high mobility group box 1 (HMGB1) and extracellular adenosine triphosphate (ATP) (12, 13). The gene discussed is HMGB1; the disease is cancer.