We therefore compared the expression of the genes mediating cytokine storm in our patient cohorts and observed that, compared to individuals with mild COVID-19, patients with severe illness showed a significant increase in IL6, IFNG, IL18, and IL1B, while dexamethasone treatment decreased the abundance of IL6, IFNG and IL18 (Figures 3A, B) (30). This evidence concerns the gene IL18 and COVID-19.