KCNA3 and COVID-19: Functional studies in CD8+ T cells, which provide a critical antiviral immune response in severe COVID-19, showed that the dexamethasone-induced changes in Kv1.3 gene expression translated into decreased channel activity, Ca2+ influx and production of IFN-γ strongly suggesting that Kv1.3 contributes to dexamethasone-mediated immunosuppression (2, 31, 65).