However, even after Omicron breakthrough infections, the AIC against all tested Omicron variants (mean spike/RBD-ACE2 inhibition: BA.1 50%, BA.2 56%, BA.2.12.2 65%, BA.3 43%, BA.4/5: 58%) was still less efficient compared to WT (89% mean spike-ACE2 inhibition) (Figure 6D). This evidence concerns the gene ACE2 and infection.