Consequently, this leads to increased expansion of memory T cells, which predispose CD300f-/- mice to develop a systemic lupus erythematosus-like autoimmune disease when exposed to an overload of apoptotic cells, or an exacerbated autoimmunity when combined with FcγRIIB deficiency (8). This evidence concerns the gene CD300LF and systemic lupus erythematosus.