The markers of 14 common tumor infiltrating immune cell types derived from TCGA data showed that tumors in subgroup 1 harbored considerably lower levels of markers of neutrophils (FCGR3A), macrophages (CD68), T cells (CD3D, CD3E), exhausted CD8+ T cells (CD244, LAG3), DCs (HSD11B1), B cells (CD19), CD8+ T cells (CD8A) and cytotoxic cells (GZMA, GZMB, KLRD1, PRF1) (blue box, Figures 3, S4-S6) (15). The gene discussed is GZMB; the disease is neoplasm.