Systems immunology triggered by MyD88- and TLRs-signaling in a wide range of immune-associated diseases, including mechanisms involved in diabetic complications (43), cardiovascular disease (44), metabolic disease (44) and other diseases associated with innate inflammatory signaling pathways (4, 45), deserves to be elusive in the context of gene-KO experiments through both experimental and computational analysis. Here, MYD88 is linked to metabolic disease.