SP/NK-1R axis exerts critical effects on multifarious cell activities, such as apoptosis, chemotaxis, and inflammation, and thus participates in regulating various physiological/pathological processes, including pain, emesis, neurological diseases (e.g., pruritus, epilepsy, Alzheimer’s disease), cardiovascular diseases (e.g., heart failure, cardiomyopathy, and myocardial infarction), inflammatory diseases (e.g., rheumatoid arthritis, osteoarthritis, and psoriasis), and cancer (13). The gene discussed is TACR1; the disease is nervous system disorder.