Aspirin protects against acute kidney injury caused by lipopolysaccharide through the TLR4/MyD88/NF-κB pathway (158).Aspirin-triggered lipoxin reduced cerebral infarction through the regulation of TLR4/NF-κB-mediated endoplasmic reticulum stress in a mouse model (159).Indobufen, aspirin, and their combinations with clopidogrel or ticagrelor reduced the symptoms of inflammasome-mediated pyroptosis in ischemic stroke by blocking the NF-κB/NLRP3 signaling pathway (160). This evidence concerns the gene NLRP3 and ischemic stroke.