Blocking corticosterone activity with the glucocorticoid receptor antagonist mifepristone, suppressed the elevation of NLRP3 and HMGB1 in unchallenged rats, regulated the proinflammatory response to LPS, and prevented memory impairment (166).Mifepristone exerted protective effects against NLRP1 inflammasome activation and prolonged dexamethasone-induced damage to hippocampus neurons (167). Here, HMGB1 is linked to memory.