NLRP3 and endometriosis: Moreover, in a mouse model of endometriosis, they showed that the loss of NLRP3 reduced the bulk of endometrial pathology (122), and suppression of endometrial infiltration through the repression of NLRP3 activation and IL-1β generation in the mouse endometrial tissues, providing evidence for the involvement of the NLRP3 inflammasome in the pathogenesis of endometriosis (123).