The preferential tumoral LCMV replication led to tumor regression through several proposed and interconnected enhanced innate and adaptive anti-tumor responses within the TME including local IFN-I production through the engagement of pattern recognition receptors, direct IFN-I anti-tumoral effects, reduced angiogenesis, recruitment of monocytes and cytotoxic CD8+ T cells to the TME and enhanced MHC I antigen presentation (17) (Figure 3). The gene discussed is CD8A; the disease is neoplasm.