IL18 and neoplasm: Furthermore, tumor-infiltrating B lymphocytes in PDAC can differentiate into IL-10- or IL-35- producing Breg cells with the help of other immune cells such as Tregs and MDSCs, cytokines (IL-18, IL-35), CAFs, tumor-associated antigens, damage-associated molecular patterns (DAMPs), hypoxia, pancreatic microbiota, and metabolites in the tumor microenvironment (7, 21, 36, 50, 51).