Aside from the well-known involvement of HIF1-α in solid tumor progression in various cancer types, HIF1-α deficiency in human pancreatic tumor samples and KC murine models resulted in increased secretion of CXCL13 and CCL21, which induces accumulation of CD19+ B cells in TME and leads to PDAC development (47). The gene discussed is CD19; the disease is pancreatic neoplasm.