TCM CD8 T cells co-expressing PD-1+ and displaying an effector memory phenotype CD44+ / CD62L+ that usually home and reside within regional lymph nodes were also found significantly more increased in tumor infiltrates originated from HVEM KO leukemia cells than in tumors originated from HVEM WT leukemia cells (Figure 5C). The gene discussed is CD8A; the disease is leukemia.