To assess the relevance of these previous findings in human diffuse large B cell lymphomas, the phenotypic pattern of chemokine receptor expression was analyzed in A20 HVEM WT and HVEM KO leukemia cells with a set of antibodies against different chemokine receptors (CXCR3, CXCR4, CXCR5, CX3CR1, CCR3, CCR5, CCR7 and CCR9). This evidence concerns the gene CXCR4 and leukemia.