Immunohistochemical analysis of retinal tissues after four months of hyperglycemia revealed a decrease in NeuN+ neuronal densities in diabetic CX3CR1-WT and hCX3CR1I249/M280 mice in comparison to the non-diabetic CX3CR1-WT (3646 ± 811.7) control group (Figures 2A, B). This evidence concerns the gene CX3CR1 and Hyperglycemia.