IL2RG and acute lymphoblastic leukemia: CD19CAR-T cells have been commonly tested in vivo in NOD-scid-IL2rγ(−/−) (NSG) and in NOD/Shi-scid IL2rγ(−/−) (NOG) mice implanted i.v. with ALL Nalm-6 cells expressing fLuc and monitored by optical imaging analyses (39, 40).