Differently from the native-like immunogens, the domain-based ones are composed by a sub-portion of the full antigen: the gp120 domain of Env of HIV (17–20), the subdomain II of DBP of P. vivax (malaria) (26), the RBD of the spike protein of MERS (30), the HA head domain (HA1) of hemagglutinin of influenza virus (33, 34) and the EDIII domain of (35, 36) viruses. This evidence concerns the gene ERVW-1 and malaria.