EPAS1 and Hepatic fibrosis: Several studies have reported that HIF-2α drives liver fibrosis by augmenting lipid accumulation, inflammation, and histidine-rich glycoprotein (Cai, Bai & Ge, 2021; Qu et al., 2011; Morello et al., 2018), but this evidence has not been supported by the fibrosis model induced by carbon tetrachloride (CCl4).