The liver/body weight in the KO + CCl4 group was lower than that in the WT + CCl4 group (Fig. 3H), but hepatocyte-specific HIF-2α deletion did not improve liver function (Figs. 3I and 3J) or glucose metabolism disorders (Figs. 3K–3M) in mice with CCl4-induced liver fibrosis. This evidence concerns the gene EPAS1 and Hepatic fibrosis.