EPAS1 and Hepatic fibrosis: Notably, we found that increased HIF-2α expression mainly occurred in the portal area and hepatic sinusoids but not in hepatocytes in mice injected intraperitoneally with CCl4 (Fig. 4G), which indicates that the hypoxia sites of CCl4-induced liver fibrosis are mainly concentrated in the portal area and hepatic sinusoids but not in hepatocytes.