Furthermore, anti-obesity and insulin sensitizing effects have also been endorsed by the modulating potential of C. odorata and coumarin on adipokinin levels (leptin, adiponectin, and chemerin), and inflammatory (TNFα, IL-6) and oxidative stress biomarkers (CAT, SOD, MDA). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.