Thiamine deficiency can decrease the production of nicotinamide adenine dinucleotide phosphate and adenosine triphosphate, which reduced the activity of transketolase and weakened the transketolase action of the pentose phosphate pathway, thereby affecting organs sensitive to hypoxia, such as the brain and heart, resulting in impaired utilization of glucose (Calderón-Ospina and Nava-Mesa, 2020). The gene discussed is TKT; the disease is Thiamine deficiency.