In ischemic stroke, mitophagy could be predominantly mediated by the PINK1/Parkin pathway, Bcl-2/E1B-19 KD-interacting protein 3 (BNIP3), NIP3-like protein X (NIX, also known as BNIP3L), and FUN14 domain containing 1 (FUNDC1). The gene discussed is BNIP3L; the disease is ischemic stroke.