IFNA1 and neoplasm: In addition, immunotherapy with intraperitoneal injection of autologous IFN-α, IFN-γ and monocytes was mainly used in OC, and the efficacy was enhanced by the synergistic killing of tumor cells by promoting the development of monocytes toward inflammatory-responsive M1-type macrophages, combined with standard chemotherapy (carboplatin and paclitaxel) (Green et al., 2016).