CD274 and neoplasm: Yang et al. demonstrated that in vivo, PD-L1 binds directly to VEGFR2, induces tumor angiogenesis, and relies on the c-JUN/PD-L1/VEGFR2 signaling axis to participate in the progression, invasion, and metastasis of OC, which provides evidence for the use of the pD-L1 inhibitor durvalumab combined with the VEGFR2 inhibitor anlotinib to improve the OC therapeutic effect (Yang et al., 2021a).