For example, platinum-resistant OC that progresses within 6 months after platinum therapy exhibits a series of “cold tumor” features, namely, low infiltration of CD8 T-cell (Mariya et al., 2014) but increased activation of CD4 T-cell, increased infiltration of regulatory T-cell (Tregs) (Hao et al., 2018) and increased infiltration of PD-L1 cells (Hamanishi et al., 2015), known to promote peritoneal dissemination (Abiko et al., 2013), in which tumor cells are in an immunosuppressive microenvironment with enhanced proliferation and migration. This evidence concerns the gene CD274 and neoplasm.