In another study (NCT02335918), it was observed in OC patients that varlilumab, a fully human agonist anti-CD27 mAb in combination with nivolumab, did not show toxicity beyond that of either monotherapy, and prolonged PFS was more pronounced at a ≥5% increase in tumor PD-L1 and intratumoral T-cell infiltration (Sanborn et al., 2022). The gene discussed is CD274; the disease is neoplasm.