Tumor angiogenesis and metastasis involve the overexpression of hypoxia inducible factor (HIF) induced by the hypoxic microenvironment in which tumor cells live (Muz et al., 2015), which further induces the transcription and translation of vascular endothelial growth factors (VEGF) protein (Semenza, 2010) (Figure 2). This evidence concerns the gene VEGFA and neoplasm.