Song et al. found that ubiquitin UBR5, a protein ligase E3, was overexpressed in human OC cells, regulating the recruitment of immunosuppressive macrophages, i.e., M2 type, to the tumor site, leading to peritoneal colonization and metastasis on the one hand and promoting cell adhesion cancer stem cell (CSC) production by controlling p53 protein levels on the other hand, suggesting that targeting UBR5 in combination with other therapeutic approaches could benefit OC patients (Song et al., 2020). This evidence concerns the gene TP53 and neoplasm.