Oral QT-loaded silk fibroin nanoparticles (QSFN) can produce obvious intestinal anti-inflammatory properties by down regulating proinflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1, ICAM-1, NLRP3, iNOS) and significantly reducing the DAI score of DSS-induced colitis mice. The gene discussed is TNF; the disease is colitis.