CS loaded with QT (QT-NPs) can downregulate inflammatory cytokines (IL-6, TNF-α, IFN-γ, IL-10) in colitis mice, upregulate tight junction protein (MUC-2, JAM-2, occludin), regulate oxidative stress state (ROS, NO, MDA, H2O2, GSH-Px, SOD, CAT, Nrf2, HO-1), restore the healthy structure of colon tissue in DSS-induced colitis mice. Here, OCLN is linked to colitis.