In line with our data, increased kidney weight was observed in SGLT2 knockout animals (Vallon et al., 2013) and other kidney disease rodent models treated with SGLT2 inhibitors (Kapoor et al., 2015; Rajasekeran et al., 2018; Castoldi et al., 2020; Yamato et al., 2020; Castoldi et al., 2021). Here, SLC5A2 is linked to kidney disorder.