NOTCH1 and neoplasm: One study showed that low dose of IFNγ endowed tumor stemness in TME of NSCLC via regulation of ICAM1/PI3K/AKT/Notch-1 pathway, whereas high dose of IFNγ induced apoptosis of NSCLC cells via activation of JAK1/STAT1/caspase pathway (Song et al., 2019).