The expression of SENP6 in microglia increases significantly after cerebral ischemia, and after downregulation of SENP6 in microglia, positive results were obtained, whereby not only did the area of cerebral infarction reduce significantly but the motor and cognitive functions of mice with cerebral ischemia also improved substantially (Mao et al., 2022). Here, SENP6 is linked to brain ischemia.