By transfecting siRNA-TRPM8 in SW480 (human colon cancer cell line) and CT26 (mouse colorectal adenocarcinoma cell line) and tissues samples from patients with colon cancer and liver metastasis, it was observed that TRPM8 upregulates vimentin, snail an N-cadherin while decreasing the expression of E-cadherin. The gene discussed is CDH2; the disease is malignant colon neoplasm.