The effect of the TRPM8 channel in PCa cells proliferation is related to the modulation of Cdk4 and Cdk6 expression (Yang et al., 2009; Yang et al., 2009; Wang et al., 2012; Asuthkar et al., 2015b; Gkika et al., 2015; Grolez et al., 2019a; Chinigò et al., 2022; Grolez et al., 2022). The gene discussed is TRPM8; the disease is posterior cortical atrophy.