It was proposed that this discrepancy is related to differences in the androgen-sensitivity of cells as TRPM8 promotes proliferation in PCa androgen-sensitive cells LNCaP, but decreases proliferation in androgen-insensitive cells PC3 and DU145 (Yang et al., 2009; Zhu et al., 2011; Wang et al., 2012; Asuthkar et al., 2015b; Grolez and Gkika, 2016). Here, TRPM8 is linked to posterior cortical atrophy.