TRPM8 and breast cancer: In the colon, oral, esophageal, bladder, and breast cancers, have been described that TRPM8 is directly involved in invasiveness and metastasis by regulation of epithelial-mesenchymal transition (EMT; Liu J. J. et al., 2022; Chen et al., 2017; Wang et al., 2020; Liu J. et al., 2014).