Among the mitogen-activated protein kinases, p38 and ERK MAPK pathways are involved in the pathogenesis of inflammatory skin diseases including AD (Johansen et al., 2005; Lee et al., 2022; Zeze et al., 2022), and the JNK pathway is also activated in atopic dermatitis (Lu et al., 2018). Here, MAPK8 is linked to inflammatory skin disease.