CD4 and Alzheimer disease: Considering the relevance of Th1, Th2, Th17, and Th22 axes to AD immunopathogenesis, we evaluated the influence of PEW on the differentiation of CD4+ Th cells in DNCB-induced AD mice by detecting the intracellular expression of IFN-γ, IL-4, IL-17A, and IL-22 using Flow cytometry assay.