NELFCD and Alzheimer disease: In the current study, the treatment of PEW showed significant potency in decreasing the frequency of Th1 and Th17 cells (Figure 5), as well as suppressing the mRNA expressions of Th1 and Th17 cytokines and nuclear transcription factors in AD-lesion inflammation (Figure 6), which indicates that PEW mainly modulates the pathogenesis of chronic AD skin inflammation.