Interestingly, PTL has been found to attenuate neuropathy pains partly via the inhibition of intracellular signalling pathways NF-κB and MEK1/2 (Popiolek-Barczyk et al., 2014; Popiolek-Barczyk et al., 2015), which would be beneficial for arthritis related pain. This evidence concerns the gene PNLIP and arthritic joint disease.