Bruton’s tyrosine kinase (BTK) is known to regulate multiple anti-apoptotic pathways, including PI3K-AKT, STAT5 and NF-kB, in B-lineage lymphoid cells (Hu et al., 2021), (Purvis et al., 2020), and has merged as an efficacious therapeutic target for the treatment of leukemia. Here, BTK is linked to leukemia.