Another study showed that sulforaphane-loaded the mineralized hyaluronic acid-SS-tetradecyl NPs (SFN/M-HA-SS-TA) inhibited breast CSCs through their specific CD44+ targeting and reduced CD44 and CD133 expression, expression of polycomb complex protein involved in the self-renewal of breast CSCs (Bmi1), and breast CSC-like properties, including tumor growth, invasiveness, and self-renewal in MDA-MB-231, Hs578t, and MCF7 cells and MDA-MB-231 mice xenografts (Gu et al., 2021). Here, CD44 is linked to neoplasm.